BAY 1082439 ( BAY 10-82439;BAY1082439 )

Catalog No. M11554 CAS No. 1375469-38-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BAY 1082439
Note

Research use only, not for human use.
Brief Description

BAY 1082439 is a potent, highly selective, orally available PI3Kα/β inhibitor, selectively inhibits both PI3Kα.
Description

BAY 1082439 is a potent, highly selective, orally available PI3Kα/β inhibitor, selectively inhibits both PI3Kα, including mutated forms of PIK3CA, and PI3Kβ in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K-expressing and/or PTEN-driven tumor cells.Solid Tumors Phase 1 Clinical
Synonyms

BAY 10-82439;BAY1082439
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1375469-38-7
Formula Weight

494.23
Molecular Formula

C25H30N6O5
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC(OC[C@@H](O)CN2CCOCC2)=C(OC)C2N=C(NC(=O)C3=CC=CN=C3C)N3CCN=C3C1=2
Chemical Name

(S)-N-(8-(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide